Malignant mesothelioma following repeated exposures to cosmetic talc: A case series of 75 patients

March 2020 - American Journal of Industrial Medicine

Theresa S. Emory MD, John C. Maddox MD, Richard L. Kradin MD

Background: Asbestos is the primary known cause of malignant mesothelioma. Some cosmetic talc products have been shown to contain asbestos. Recently, repeated exposures to cosmetic talc have been implicated as a cause of mesothelioma.

Methods: Seventy-five individuals (64 females; 11 males) with malignant mesothelioma, whose only known exposure to asbestos was repeated exposures to cosmetic talcum powders, were reviewed in medical-legal consultation. Out of the 75 cases, 11 were examined for asbestiform fibers.

Results: All subjects had pathologically confirmed malignant mesothelioma.

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Mesothelioma Associated With Use of Cosmetic

January 2020 - American College of Occupational and Environmental Medicine

Jacqueline Moline, MD, MSc, Kristin Bevilacqua, MPH, Maya Alexandri, JD, and Ronald E. Gordon, PhD

Objective: To describe 33 cases of malignant mesothelioma among individuals with no known asbestos exposure other than cosmetic talcum powder.

Methods: Cases were referred for medico-legal evaluation, and tissue digestions were performed in some cases. Tissue digestion for the six cases described was done according to standard methodology.

Results: Asbestos of the type found in talcum powder was found in all six cases evaluated. Talcum powder usage was the only source of asbestos for all 33 cases. Conclusions: Exposure to asbestos-contaminated talcum powders can cause mesothelioma. Clinicians should elicit a history of talcum powder usage in all patients presenting with mesothelioma.

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Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations

2014 - Scandinavian Journal of Work, Environment & Health

Henrik Wolff, MD, PhD, Tapio Vehmas, MD, PhD, Panu Oksa, MD, PhD, Jorma Rantanen, MD, PhD, Harri Vainio, MD, PhD

Although the use of asbestos has been banned in several industrialized countries, many workers continue to be exposed in asbestos repair and removal work, and asbestos is still widely used in various newly industrialized, rapidly developing countries. According to the most recent World Health Organization (WHO) estimates, more than 107 000 people die each year from asbestos-related lung cancer, mesothelioma, and asbestosis resulting from exposure at work.

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Chrysotile Asbestos as a Cause of Mesothelioma: Application of the Hill Causation Model

2004 - International Journal of Occupational and Environmental Health

Richard A. Lemen, PhD

Chrysotile comprises over 95% of the asbestos used today. Some have contended that the majority of asbestos-related diseases have resulted from exposures to the amphiboles. In fact, chrysotile is being touted as the form of asbestos which can be used safely. Causation is a controversial issue for the epidemiologist. How much proof is needed before causation can be established?

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Tremolite and Mesothelioma

2002

Victor L. Roggli, Robin T. Vollmer, Kelly J. Butnor and Thomas A. Sporn

Background: Exposure to chrysotile dust has been associated with the development of mesothelioma and recent studies have implicated contaminating tremolite fibers as the likely etiological factor

Methods: We examined 312 cases of mesothelioma for which fiber burden analysis of lung parenchyma had been performed by means of scanning electron microscopy to determine the content of tremolite, non-commercial amphiboles, talc and chrysotile. The vast majority of these patients were exposed to dust from products containing asbestos.

Results: Tremolite was identified in 166 of 312 cases (53%) and was increased above background levels in 81 cases (26%). Fibrous talc was identified in 193 cases (62%) and correlated strongly with the tremolite content.

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Talc Should Not Be Used for Pleurodesis in Patients with Nonmalignant Pleural Effusions

2001 - American Journal of Respiratory and Critical Care Medicine

Andrew J. Ghio, Victor Roggli, and Author Affiliations

In the debate regarding the use of talc in pleurodesis, respiratory failure after intrapleural injection was cited as that complication potentially limiting employment of this agent. We agree with this appraisal in the treatment of patients with malignant recurrent effusions. However, there should continue to be concern regarding the use of talc for pleurodesis in individuals with nonmalignant pleural effusions and spontaneous pneumothorax. This dilemma results from a possible increased risk of malignant mesothelioma in those patients treated with talc. Consequently, an alternative agent should be employed in any individual without malignancy requiring pleurodesis.

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Pathology of Asbestos-Associated Diseases – 1st Edition

1992 - Little Brown & Co

Victor L Roglie, Donald Greenberg and Philip C. Pratt

Page 194

Epidemiologic data indicates that carcinoma of the lung may develop in response to exposure to any types of asbestos. However, there is considerable controversy regarding the relative potency of the various fiber types for the production of pulmonary neoplasm.

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